Neomycin for Cats: Overview, Dosage & Side Effects

Neomycin is an antibiotic most often used in veterinary medicine as part of a triple combination topical medication for disorders of the eye. In this article, you’ll learn about how neomycin acts against bacteria, formulations it comes in, side effects and precautions to be aware of, and some frequently asked questions.

Neomycin for Cats Overview

Medication Type:

Aminoglycoside antibiotic

Form:

Oral tablets, topical or ophthalmic combination preparations

Prescription Required?:

Yes for oral form and most topical medications. Some OTC topical forms are available.

FDA Approved?:

The oral form is not. Some topical combination preparations, like Tresaderm, are FDA approved for use in cats.

Brand Names:

Oral: Biosol, Neomix; Numerous topical combination preparations both prescription and OTC contain neomycin (Tresaderm, Vetropolycin, Entederm, Animax, Quadritop, Neosporin)

Common Names:

Neomycin

Available Dosages:

Oral neomycin sulfate tablets: 500mg

Expiration Range:

In a dry state, neomycin is stable for at least 2 years when stored at room temperature. For topical combination products, always use the product before the expiration date on the package.

About Neomycin for Cats

Neomycin is an aminoglycoside antibiotic. This class of antibiotics acts on bacteria by interfering with the bacteria’s ability to synthesize certain proteins needed for their growth and reproduction.

Aminoglycosides, which also include antibiotics like amikacin and gentamicin, primarily act against aerobic, or oxygen dependent, gram-negative staining bacteria like Pseudomonas and Enterobacter. They can also have some effect against gram-positive staining bacteria.

Neomycin comes in both oral and topical forms. The oral form is uncommonly used in veterinary medicine, but may be rarely considered in cases to reduce bacterial growth in the digestive tract. This may be in preparation for a procedure like colon surgery, or to reduce ammonia-producing bacteria that are contributing to signs of a liver disorder called hepatic encephalopathy.

Oral neomycin is not well absorbed, and so its general use as an oral antibiotic is very limited. The injectable form comes with significant concerns for kidney toxicity, making its other injectible antibiotic cousins more likely choices if indicated.

Neomycin is most often used as a topical preparation for the skin and eyes. Usually, it is in combination with two or more other ingredients to make a “triple” antibiotic ointment. Examples include neomycin with polymyxin B and gramicidin or bacitracin, and neomycin with polymyxin B and dexamethasone.

Tresaderm, which is labeled for use in cats for topical treatment of skin and ear infections, contains neomycin along with the corticosteroid dexamethasone, and antifungal thiabendazole.

What Does Neomycin Do for Cats?

Most commonly, neomycin may be used topically in cats for small wounds on the skin, local areas of bacterial infection, and for ear infections caused by bacteria.

It is also common to use neomycin ophthalmic ointment preparations for eye disorders where bacterial infection is thought to be involved, like corneal scratches, corneal ulcers, conjunctivitis (infection of the eyes under the lids), or blepharitis (infection of the lids themselves).

Side Effects of Neomycin for Cats

Neomycin may be used topically to treat small wounds on the skin, local areas of infection, and ear infections.

Some cats can have a topical hypersensitivity or reaction to either neomycin, polymyxin B (which it is often paired with) or both.

At the low end, this may be seen as itching, scratching, or irritation at the application site. At worse, a severe allergic or anaphylactic reaction may occur.

Fortunately, this type of reaction has not been associated with products containing a steroid (like dexamethasone, hydrocortisone, betamethasone, or triamcinolone).

As a majority of neomycin products used in veterinary medicine do contain a steroid to address skin or eye inflammation, serious reactions to most veterinary products appear to be uncommon.

But because neomycin is a common ingredient in many over-the-counter triple antibiotic ointment products that don’t contain steroids (Neosporin, etc.), it’s important to always look at the ingredients of any OTC product you plan to use for your pet, and check with your veterinarian before using it.

Any eye medication containing a steroid has the potential to worsen disease if a corneal ulcer is present. A corneal ulcer is where a scratch or abrasion on the eye gets infected and starts to erode the corneal surface.

This is why it is very important not to use a steroid-containing medication in the eye unless you have been directed to do so by your veterinarian. During an exam of an eye issue, a veterinarian will often apply a stain called fluorescein to the eye to check for the presence of an ulcer and make sure that using a product containing a steroid is safe.

It’s also very important to be aware of the form or type of neomycin topical preparation you have. There are brands and generic products for skin, ear, and eye products and it is very important not to use skin/ear products in the eyes.

Neomycin for Cats Dosage

Your veterinarian will instruct you how to give neomycin, including how much and how often to give it your cat.

For most topical eye preparations, a single drop or about a ¼-inch strip of ointment is used, anywhere from twice a day up to three to four times per day in the affected eye.

For other topical preparations for the skin and ears, application every 12 hours is common. But it’s important to follow your veterinarian’s instructions, as application amount and frequency may differ depending on what is being treated.

For the oral form of neomycin, a dose is not provided here, as it is an uncommonly used form except for very specific circumstances and in those cases, a veterinarian’s instructions should be closely followed.

Conclusion

While the oral form is uncommonly utilized in veterinary medicine, neomycin is a very common ingredient in topical preparations for the eyes, ears, and skin.

Some cats may have allergic sensitivities to neomycin, which is seen less commonly in combination products also containing a steroid.

It’s always important to check first with your vet before using an over-the-counter product containing neomycin, or a previous prescription product containing neomycin that you may still have at home.

Drug Dosing Disclaimer: We are only able to provide doses for medications that are FDA approved for use in cats and only as the label guidelines dictate. For medications that are used off-label we can only provide guidelines and safety information for use. Safe and appropriate dosing for off-label medications can only be determined by a primary care veterinarian.

We encourage you to work with your veterinarian to determine if a particular medication is appropriate for your cat. Changing or adjusting a dose for your cat on your own without consulting with a veterinarian can carry risk. We do not encourage use of medications prescribed for human use in pets without first consulting with a primary care veterinarian.